Mifepristone (ru-486) and Its Analogues
نویسندگان
چکیده
Mifepristone (RU-486) is the first antiprogesterone drug used for the termination of early pregnancies (6 to 8 weeks pregnancies), a steroid synthesized in the laboratory. It has higher affinity for the progesterone receptor. It also has other potential applications as anticancer and glucocorticoid antagonist. It is desirable to increase its antiprogestational potency and eliminate the antiglucocorticoid property. Therefore, an intense effort is directed towards the synthesis of mifepristone analogues and study their biological activity. This review gives an account of the research carried out in this area.
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تاریخ انتشار 1956